Endocrine Abstracts

Introduction: Cochleovestibular disorders in patients with diabetes is not well known as compared to other complications. The aim of this study was to evaluate the epidemiological, clinical and paraclinical characteristics of cochleovestibular dysfunction in diabetes.Materials and Methods: This is a retrospective study of 100 diabetic patients. The patients had a clinical otological and vestibular examination as well as a tonal audiometry and a video nys...

Introduction: Metabolic syndrome (MS) is responsible for the increased cardiovascular risk in type 2 diabetics, but few studies have looked at the metabolic syndrome in type 1 diabetics. The aim of This study is to evaluate the prevalence of microvascular and macrovascular complications and evaluate the cardiovascular risk among patients with T1DM associated with metabolic syndrome.Materials and Methods: Retrospective study which included 36 type 1 diabe...

Introduction: Gonadal tumors are rare in children. Because surgery is the primary treatment for ovarian tumors, ovarian salvage with fertility preservation and use of a minimally invasive surgical technique are important in children and adolescents. We report the case of an adolescent girl who was referred after bilateral annexectomy. Observation: This is a 14-year-old girl who just had her first menses. She has been followed the last year for an ovarian...

Introduction: Multiple endocrine neoplasia type 2 (MEN2) is a rare inherited disease characterized by the occurrence of medullary thyroid cancer (MTC) either isolated or associated with pheochromocytoma, primary hyperparathyroidism (PHP), or typical morphological features. Thus, we report two cases.Patient(1): A 27-year-old female patient with a marfanoid appearance, had a histologically confirmed conjunctival and mucosal ganglioneuromatosis, bilateral c...

Introduction: Insulinoma is a rare pancreatic tumor. It is the most frequent cause of organic hypoglycemia due to endogenous hyperinsulinism.Case report: A 55-year-old woman was admitted in our department for the management of a recurrent hypoglycemic coma. Endogenous hyperinsulinic hypoglycemia was confirmed with a spontaneous hypoglycemia. Plasma blood glucose was 0.25 g/l concomitant to a high insulinemia of 31.5 µUI/ml (≥ 3) and C-peptide ...

Introduction: Giant prolactinomas (GP), defined as prolactinomas ≥4 cm in maximum dimension, are uncommon, with reported prevalence of 2 to 3% of all prolactinomas. Aim: The aim of this study is to describe clinical and paraclinical characteristics of GP and to identify predictors of therapeutic response.Matherials and methods: A retrospective, single-center, descriptive study including 18 patients with GP followed at the end...

Introduction: The nephrogenic diabetes insipidus (DI) is an entity to be known. It is essential to know its etiologies and especially its therapeutic modalities which are different from those of the central DI. The familial nature of the disease should suggest a genetic origin. In our paper, we are presenting the case of a Tunisian family with genetic nephrogenic DI.Case reports: Our family had a history of neglected polyuro-polydipsic syndrome (PPS), de...

Introduction: Tuberculosis is an infectious disease that involves any organ. However, the primary pituitary tuberculosis is an extremely rare disease. Intracranial tuberculomas account for 0,15-5% of intracranial space-occupying lesions, of which pituitary as the primary site, and easily misdiagnosed as pituitary adenoma. In this setting, the late diagnosis can result in permanent endocrine dysfunction. We hereby report the case of a patient with pituita...

Introduction and aim: Dopamine agonists (DA) are prescribed as first-line treatment for prolactinomas and are generally effective and well tolerated. However, the degree and quickness of therapeutic response is variable among patients. The aim of this work is to study the predictive factors of biological remission in patients with prolactinoma treated with DA. Methods: A single-center, retrospective and analytical study of patients with prolactinoma foll...

Introduction: Empty sella syndrome (ESS) is a rare condition in which the sella turcica is partially or completely filled with cerebrospinal fluid. It can be primary or secondary. Ophthalmologic involvement is rare in primary empty sella Syndrome. It is described in only 1.6 to 16% of cases. Patients and methods: We report a retrospective study of 46 cases of ESS collected in the endocrinology department over the period from 1991 to 2020. The clinical an...